If you have 3 soul after the second wave, you can do the optimal damage rotation for Traitor Lord pretty reliably without scream skipping. By itself this saves 0.3 because of no freeze frames, but if you are 1HP after frogs you save an additional 2 seconds because you don't have to heal and then get soul.
Go for the double on the first wave and then go for double double on the second wave. For every double you miss, get 3 nail hits and fireball so you still end with a cast. The only meaningful downside is if Traitor Lord does three grounded dashes in a row, it's really hard and maybe not possible to get enough soul hits to do the last double, so you'll have to get 3 extra nail hits and fireball, but this is still faster than healing.
Stand at this pillar then nail slash twice and instantly release cdash, can't go to fast in testing, but sometimes looks like you go through the gate :Burgy:
Here is all the boss battles in 112 and 107 where flukenest has been found to be either optimal or viable/ preferable over the non flukes alternative. I will first post the unambiguously optimal fights and then post the ones which may come to preference.
Nosk: Good RNG fight saves 10 seconds over non flukes combsob. Bad rng isn't super punishing as nosk has a lot of attacks where he can get multihit, you shouldn't be losing more than 5 seconds. If he goes into the ceiling instantly you can shriek as usual.
The charm loadout is: Shaman stone, spell twister and flukenest, needs overcharming.
Collector: There is a completely consistent quickkill which has been posted in strats before. Additionally, flukes will instakill collector out of the final phase. In total this is seven seconds of timesave over perfect shriek only fight.
Charm loadout is shaman stone, flukenest and dreamwielder. Charm switch optimally at tram bench or at oro bench for a safety heal.
Watcher Knights: Saves 5 seconds on average over optimal shriek fight. Each watcher dies in three fluke casts, so you can kill them before they even attack. To make up for the lack of twister i have come up with a couple of strats to gather soul (showcased in video). Its still optimal to throw the chandelier down, and the fight needs to be started with full soul.